Article
Pyrimidine base damage is increased in women with BRCA mutations.
Cancer letters - 28 Sept 2013
Budzinski Edwin E, Patrzyc Helen B, Dawidzik Jean B, Freund Harold G, Frederick Peter, Godoy Heidi E, Voian Nicoleta C, Odunsi Kunle, Box Harold C
Abstract excerpt
Oxidatively-induced DNA damage was measured in the DNA of WBC from two groups of women: carriers of a BRCA mutation, but asymptomatic for disease, and healthy controls. Two oxidatively induced lesions were measured: a formamide remnant of pyrimidine base and the glycol modification of thymine. These lesions, employed previously in studies of the effects of smoking, antioxidant usage and ovarian cancer, are...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.