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Article

Oxidation of DNA and RNA in young patients with newly diagnosed bipolar disorder and relatives.

Translational psychiatry - 8 Feb 2024

Coello Klara, Mäkinen Ilari Jaakko Olavi, Kjærstad Hanne Lie, Faurholt-Jepsen Maria, Miskowiak Kamilla Woznica, Poulsen Henrik Enghusen, Vinberg Maj, Kessing Lars Vedel

Abstract excerpt

Excessive oxidative stress-generated nucleoside damage seems to play a key role in bipolar disorder (BD) and may present a trait phenomenon associated with familial risk and is one of the putative mechanisms explaining accelerated atherosclerosis and premature cardiovascular diseases (CVD) in younger patients with BD. However, oxidative stress-generated nucleoside damage has not been studied in young BD patients...

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PMID: 38331875
DOI: 10.1038/s41398-024-02772-8
PMCID: PMC10853262

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