Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lymphoblasts of women with BRCA1 mutations are deficient in cellular repair of 8,5'-Cyclopurine-2'-deoxynucleosides and 8-hydroxy-2'-deoxyguanosine.

Biochemistry - 6 Mar 2007

Rodriguez Henry, Jaruga Pawel, Leber Dennis, Nyaga Simon G, Evans Michele K, Dizdaroglu Miral

Abstract excerpt

Mutations in breast and ovarian cancer susceptibility genes BRCA1 and BRCA2 predispose women to a high risk of these cancers. Here, we show that lymphoblasts of women with BRCA1 mutations who had been diagnosed with breast cancer are deficient in the repair of some products of oxidative DNA damage, namely, 8-hydroxy-2'-deoxyguanosine and 8,5'-cyclopurine-2'-deoxynucleosides. Cultured lymphoblasts from 10...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 8-Hydroxy-2'-Deoxyguanosine
Share to Chromatography, Liquid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Deoxyguanosine

Share to DNA Damage

Share to Gas Chromatography-Mass Spectrometry

Share to Genes, BRCA1

Share to Mass Spectrometry

Share to Oxidation-Reduction

Source

Identifiers

PMID: 17288454
DOI: 10.1021/bi062022p

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lymphoblasts of women with BRCA1 mutations are deficient in cellular repair of 8,5'-Cyclopurine-2'-deoxynucleosides and 8-hydroxy-2'-deoxyguanosine.PMID 17288454Read ↗

BRCA1 and BRCA2 protect against oxidative DNA damage converted into double-strand breaks during DNA replication.Semantic proximity Read ↗

Ionizing radiation-induced DNA injury and damage detection in patients with breast cancerSemantic proximity Read ↗

DNA damage and breast cancerSemantic proximity Read ↗

Elevated level of 8-oxo-7,8-dihydro-2'-deoxyguanosine in leukocytes of BRCA1 mutation carriers compared to healthy controls.Semantic proximity Read ↗

Oxidative DNA damage and 8‐hydroxy‐2‐deoxyguanosine DNA glycosylase/apurinic lyase in human breast cancerSemantic proximity Read ↗

Identification of distinct and common gene expression changes after oxidative stress and gamma and ultraviolet radiation.Semantic proximity Read ↗

A sensitive test for the detection of specific DSB repair defects in primary cells from breast cancer specimens.Semantic proximity Read ↗

Induction and processing of complex DNA damage in human breast cancer cells MCF-7 and nonmalignant MCF-10A cellsSemantic proximity Read ↗

Molecular contribution of BRCA1 and BRCA2 to genome instability in breast cancer patients: review of radiosensitivity assaysSemantic proximity Read ↗

Interplay between BRCA1 and GADD45A and Its Potential for Nucleotide Excision Repair in Breast Cancer PathogenesisSemantic proximity Read ↗

Initiation of DNA interstrand cross‐link repair in mammalian cellsSemantic proximity Read ↗

Reduced repair capacity of a DNA clustered damage site comprised of 8-oxo-7,8-dihydro-2'-deoxyguanosine and 2-deoxyribonolactone results in an increased mutagenic potential of these lesions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.