Article
Anti-genotoxic potential of bilirubin in vivo: damage to DNA in hyperbilirubinemic human and animal models.
Cancer prevention research (Philadelphia, Pa.) - 1 Oct 2013
Wallner Marlies, Antl Nadja, Rittmannsberger Barbara, Schreidl Stephanie, Najafi Khatereh, Müllner Elisabeth, Mölzer Christine, Ferk Franziska, Knasmüller Siegfried, Marculescu Rodrig, Doberer Daniel, Poulsen Henrik E, Vitek Libor, Bulmer Andrew C, Wagner Karl-Heinz
Abstract excerpt
The bile pigment bilirubin is a known antioxidant and is associated with protection from cancer and cardiovascular disease (CVD) when present in too strong concentrations. Unconjugated bilirubin (UCB) might also possess anti-genotoxic potential by preventing oxidative damage to DNA. Moderately elevated bilirubin levels are found in individuals with Gilbert syndrome and more severe in the hyperbilirubinemic Gunn...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.