Article
DNA base modifications in chromatin of human cancerous tissues.
FEBS letters - 7 Sept 1992
Olinski R, Zastawny T, Budzbon J, Skokowski J, Zegarski W, Dizdaroglu M
Abstract excerpt
Free radical-induced damage to DNA in vivo is implicated to play a role in carcinogenesis. Evidence exists that DNA damage by endogenous free radicals occurs in vivo, and there is a steady-state level of free radical-modified bases in cellular DNA. We have investigated endogenous levels of typica...
Topics
- Chromatin
- Chromatography
- DNA Damage
- DNA, Neoplasm
- Free Radicals
- Humans
- Hydroxides
- Hydroxyl Radical
- Mutation
- Neoplasms
- Purines
- Pyrimidines