Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA base modifications in chromatin of human cancerous tissues.

FEBS letters - 7 Sept 1992

Olinski R, Zastawny T, Budzbon J, Skokowski J, Zegarski W, Dizdaroglu M

Abstract excerpt

Free radical-induced damage to DNA in vivo is implicated to play a role in carcinogenesis. Evidence exists that DNA damage by endogenous free radicals occurs in vivo, and there is a steady-state level of free radical-modified bases in cellular DNA. We have investigated endogenous levels of typical free radical-induced DNA base modifications in chromatin of various human cancerous tissues and their cancer-free...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin
Share to DNA Damage
Share to DNA, Neoplasm

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Free Radicals

Share to Mutation

Share to Neoplasms

Share to Purines

Share to Pyrimidines

Source

Identifiers

PMID: 1324197
DOI: 10.1016/0014-5793(92)81093-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA base modifications in chromatin of human cancerous tissues.PMID 1324197Read ↗

Modification of DNA bases in mammalian chromatin by radiation-generated free radicals.Semantic proximity Read ↗

Mass spectrometric profiling of DNA adducts in the human stomach associated with damage from environmental factorsSemantic proximity Read ↗

Nucleic Acid Adductomics – the Next Generation of Adductomics for Assessing Environmental Health RiskSemantic proximity Read ↗

Urinary DNA adductomics – A novel approach for exposomicsSemantic proximity Read ↗

Tissue- and sex-specific DNA damage tracks aging in rodents and humansSemantic proximity Read ↗

Mutagenic potential of hypoxanthine in live human cells.Semantic proximity Read ↗

Screening DNA Damage in the Rat Kidney and Liver by Untargeted DNA AdductomicsSemantic proximity Read ↗

Gender Differences in Steady-state Levels of Oxidative Damage to DNA in Healthy IndividualsSemantic proximity Read ↗

Mutagenic potentials of damaged nucleic acids produced by reactive oxygen/nitrogen species: approaches using synthetic oligonucleotides and nucleotides: survey and summary.Semantic proximity Read ↗

Pyrimidine base damage is increased in women with BRCA mutations.Semantic proximity Read ↗

DNA adducts: Formation, biological effects, and new biospecimens for mass spectrometric measurements in humans.Semantic proximity Read ↗

Analysis and Identification of 2′-Deoxyadenosine-Derived Adducts in Lung and Liver DNA of F-344 Rats Treated with the Tobacco-Specific Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and Enantiomers of its Metabolite 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanolSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.