Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Elevated level of 8-oxo-7,8-dihydro-2'-deoxyguanosine in leukocytes of BRCA1 mutation carriers compared to healthy controls.

International journal of cancer - 1 Nov 2009

Dziaman Tomasz, Huzarski Tomasz, Gackowski Daniel, Rozalski Rafal, Siomek Agnieszka, Szpila Anna, Guz Jolanta, Lubinski Jan, Olinski Ryszard

Abstract excerpt

Carriers of BRCA1 mutation face highly increased risk of breast and ovarian cancer and some studies with cell culture suggest that the encoded protein may be involved in oxidatively damaged DNA repair. However, no studies concerning a possible link between oxidatively damaged DNA and BRCA1 defici...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to Deoxyadenosines
Share to DNA Damage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, BRCA1

Share to Heterozygote

Share to Leukocytes

Share to Ovarian Neoplasms

Share to Oxidative Stress

Source

Identifiers

PMID: 19623658
DOI: 10.1002/ijc.24600

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-19623658-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Elevated level of 8-oxo-7,8-dihydro-2'-deoxyguanosine in leukocytes of BRCA1 mutation carriers compared to healthy controls.PMID 19623658Read ↗

Selenium supplementation reduced oxidative DNA damage in adnexectomized BRCA1 mutations carriers.Semantic proximity Read ↗

Lymphoblasts of women with BRCA1 mutations are deficient in cellular repair of 8,5'-Cyclopurine-2'-deoxynucleosides and 8-hydroxy-2'-deoxyguanosine.Semantic proximity Read ↗

Oxidative DNA damage and 8‐hydroxy‐2‐deoxyguanosine DNA glycosylase/apurinic lyase in human breast cancerSemantic proximity Read ↗

Influence of the OGG1 Ser326Cys polymorphism on oxidatively damaged DNA and repair activity.Semantic proximity Read ↗

DNA repair activity of 8-oxoguanine DNA glycosylase 1 (OGG1) in human lymphocytes is not dependent on genetic polymorphism Ser326/Cys326.Semantic proximity Read ↗

Association between DNA damage, DNA repair genes variability and clinical characteristics in breast cancer patients.Semantic proximity Read ↗

Could 8-oxoguanine DNA glycosylase 1 Ser326Cys polymorphism be a biomarker of susceptibility in cancer?Semantic proximity Read ↗

DNA repair enzyme polymorphisms and oxidative stress in a Turkish population with gastric carcinoma.Semantic proximity Read ↗

The role of base excision repair in pathogenesis of breast cancer in the Polish population.Semantic proximity Read ↗

The 8-hydroxydeoxyguanosine concentrations according to hormone therapy and S326C polymorphism of OGG1 gene in postmenopausal women.Semantic proximity Read ↗

Circadian Modulation of 8-Oxoguanine DNA Damage RepairSemantic proximity Read ↗

Impact of the Ser326Cys polymorphism of the OGG1 gene on the level of oxidative DNA damage in patients with colorectal cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.