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Article

Modification of DNA bases in mammalian chromatin by radiation-generated free radicals.

Biochemistry - 28 Aug 1990

Gajewski E, Rao G, Nackerdien Z, Dizdaroglu M

Abstract excerpt

Modification of DNA bases in mammalian chromatin in aqueous suspension by ionizing radiation generated free radicals was investigated. Argon, air, N2O, and N2O/O2 were used for saturation of the aqueous system in order to provide different radical environments. Radiation doses ranging from 20 to 200 Gy (J.kg-1) were used. Thirteen products resulting from radical interactions with pyrimidines and purines in...

Topics

Animals
Argon
Chromatin
DNA
Free Radicals
Gases
Mammals
Mutation
Nitrites
Oxygen
Radiation, Ionizing

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 2261442
DOI: 10.1021/bi00486a014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2261442-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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