Article
KIT mutations in mast cell tumours from cheetahs (Acinonyx jubatus) and domestic cats (Felis catus).
Veterinary and comparative oncology - 1 Jun 2021
Tamlin Vanessa S, Bottema Cynthia D K, Campbell-Ward Michelle L, Hanshaw Daren, Peaston Anne E
Abstract excerpt
Mast cell tumours (MCT) have been documented in numerous species and mutations within the KIT proto-oncogene are implicated in the neoplastic biology of mast cells in humans, dogs and cats. This study determined high KIT gene nucleotide and Kit amino acid sequence homology between several species known to suffer mast cell neoplasia and especially high sequence conservation between the cheetah (Acinonyx jubatus)...
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