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Article

c-kit mutational analysis in paraffin material.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2013

Sotlar Karl

Abstract excerpt

The current WHO classification of mastocytosis defines one major and four minor diagnostic criteria for systemic mastocytosis (SM). One of the minor criteria is the detection of the "gain-of-function" mutation D816V of the c-kit proto-oncogene in extracutaneous organs. The receptor molecule KIT is a potential therapeutic target for tyrosine kinase inhibitors. KIT mutations have been described in more than 80% of...

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Source

Identifiers

PMID: 23666690
DOI: 10.1007/978-1-62703-357-2_4

Genes

KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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