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Article

Characterization of a novel CYP2C9 gene mutation and structural bioinformatic protein analysis in a warfarin hypersensitive patient.

Pharmacogenetics and genomics - 1 Jun 2011

Ciccacci Cinzia, Falconi Mattia, Paolillo Nicoletta, Oteri Francesco, Forte Vittorio, Novelli Giuseppe, Desideri Alessandro, Borgiani Paola

Abstract excerpt

Warfarin (coumadin) is a worldwide-prescribed anticoagulant for the long-term treatment and prevention of thromboembolic events, presenting a great interindividual variability in the required dose. It is known that both environmental and genetic factors influence the dose necessary for the therapeutic effect. Herein we describe a pharmacogenetic study conducted on an Italian patient with warfarin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2C9

Share to Cytochrome P-450 Enzyme System

Share to Cytochrome P450 Family 4

Share to Mixed Function Oxygenases

Share to Vitamin K Epoxide Reductases

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Source

Identifiers

PMID: 21451434
DOI: 10.1097/FPC.0b013e328344c340

Genes

VKORC1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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