Article
[Pharmacogenetics and interindividual variability in drug response: cytochrome P-450 2C9 and coumarin anticoagulants].
Bulletin de l'Academie nationale de medecine - 1 Jan 2006
Becquemont Laurent, Verstuyft Céline, Jaillon Patrice
Abstract excerpt
Pharmacogenetics, a discipline still in its infancy, is the study of genetically determined variations in how individuals respond to drugs. Mutations may affect drug metabolism, transmembrane transport into cells, or target receptors. Genetic polymorphisms affecting drug metabolism were the first...
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