Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

c-Abl phosphorylates E6AP and regulates its E3 ubiquitin ligase activity.

Biochemistry - 7 May 2013

Chan Ai-Leen, Grossman Tamar, Zuckerman Valentina, Campigli Di Giammartino Dafne, Moshel Ofra, Scheffner Martin, Monahan Brendon, Pilling Pat, Jiang Yong-Hui, Haupt Sue, Schueler-Furman Ora, Haupt Ygal

Abstract excerpt

In human papillomavirus (HPV)-infected cells, the p53 tumor suppressor is tightly regulated by the HPV-E6-E6AP complex, which promotes it for proteasomal degradation. We previously demonstrated that c-Abl tyrosine kinase protects p53 from HPV-E6-E6AP complex-mediated ubiquitination and degradation under stress conditions. However, the underlying mechanism was not defined. In this study, we explored the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Western
Share to Catalytic Domain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Line

Share to Phosphorylation

Share to Proto-Oncogene Proteins c-abl

Share to Sequence Homology, Amino Acid

Share to Ubiquitin-Protein Ligases

Share to Ubiquitination

Source

Identifiers

PMID: 23581475
DOI: 10.1021/bi301710c

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

c-Abl phosphorylates E6AP and regulates its E3 ubiquitin ligase activity.PMID 23581475Read ↗

c-Abl Regulates p53 Levels under Normal and Stress Conditions by Preventing Its Nuclear Export and UbiquitinationSemantic proximity Read ↗

Requirement of E6AP and the features of human papillomavirus E6 necessary to support degradation of p53.Semantic proximity Read ↗

Human papillomavirus type 16 E6 induces self-ubiquitination of the E6AP ubiquitin-protein ligase.Semantic proximity Read ↗

Human papillomavirus E6-induced degradation of E6TP1 is mediated by E6AP ubiquitin ligase.Semantic proximity Read ↗

Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade.Semantic proximity Read ↗

E6-Associated Protein Is Required for Human Papillomavirus Type 16 E6 to Cause Cervical Cancer in MiceSemantic proximity Read ↗

Activating transcription factor 3 activates p53 by preventing E6-associated protein from binding to E6.Semantic proximity Read ↗

The Human Papillomavirus (HPV) E6* Proteins from High-Risk, Mucosal HPVs Can Direct Degradation of Cellular Proteins in the Absence of Full-Length E6 ProteinSemantic proximity Read ↗

The role of E6AP in the regulation of p53 protein levels in human papillomavirus (HPV)-positive and HPV-negative cells.Semantic proximity Read ↗

Structure of the p53 degradation complex from HPV16Semantic proximity Read ↗

PKN Binds and Phosphorylates Human Papillomavirus E6 OncoproteinSemantic proximity Read ↗

High-Risk Human Papillomavirus E6 Oncoproteins Interact with 14-3-3ζ in a PDZ Binding Motif-Dependent MannerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.