Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Downregulation of FOXP1 is required during germinal center B-cell function

12 Apr 2013

Abstract excerpt

B-cell maturation and germinal center (GC) formation are dependent on the interplay between BCL6 and other transcriptional regulators. FOXP1 is a transcription factor that regulates early B-cell development, but whether it plays a role in mature B cells is unknown. Analysis of human tonsillar B-cell subpopulations revealed that FOXP1 shows the opposite expression pattern to BCL6, suggesting that FOXP1 regulates...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Immune Cell Function and Interaction
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23580662
DOI: 10.1182/blood-2012-10-462846

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Downregulation of FOXP1 is required during germinal center B-cell functionPMID 23580662Read ↗

The forkhead transcription factor FOXP1 represses human plasma cell differentiationSemantic proximity Read ↗

Foxp1 is an essential transcriptional regulator for the generation of quiescent naive T cells during thymocyte development.Semantic proximity Read ↗

FOXP1 is a regulator of quiescence in healthy human CD4+ T cells and is constitutively repressed in T cells from patients with lymphoproliferative disorders.Semantic proximity Read ↗

N-terminally truncated FOXP1 protein expression and alternate internal FOXP1 promoter usage in normal and malignant B cellsSemantic proximity Read ↗

FOXP1 directly represses transcription of proapoptotic genes and cooperates with NF-κB to promote survival of human B cellsSemantic proximity Read ↗

Foxp4 Is Dispensable for T Cell Development, but Required for Robust Recall ResponsesSemantic proximity Read ↗

Subtype-specific addiction of the activated B-cell subset of diffuse large B-cell lymphoma to FOXP1Semantic proximity Read ↗

Potentially oncogenic B-cell activation–induced smaller isoforms of FOXP1 are highly expressed in the activated B cell–like subtype of DLBCLSemantic proximity Read ↗

The significance of FOXP1 in diffuse large B-cell lymphoma.Semantic proximity Read ↗

Foxp3: a genetic foundation for regulatory T cell differentiation and function.Semantic proximity Read ↗

FOXP3: genetic and epigenetic implications for autoimmunity.Semantic proximity Read ↗

Analyses of a Mutant Foxp3 Allele Reveal BATF as a Critical Transcription Factor in the Differentiation and Accumulation of Tissue Regulatory T Cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.