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FOXP1 directly represses transcription of proapoptotic genes and cooperates with NF-κB to promote survival of human B cells

30 Sept 2014

Abstract excerpt

The forkhead transcription factor FOXP1 is involved in B-cell development and function and is generally regarded as an oncogene in activated B-cell-like subtype of diffuse large B-cell lymphoma (DLBCL) and mucosa-associated lymphoid tissue lymphoma, lymphomas relying on constitutive nuclear factor κB (NF-κB) activity for survival. However, the mechanism underlying its putative oncogenic activity has not been...

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PMID: 25267198
DOI: 10.1182/blood-2014-01-553412

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