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Article

Subtype-specific addiction of the activated B-cell subset of diffuse large B-cell lymphoma to FOXP1

19 Jan 2016

Abstract excerpt

High expression of the forkhead box P1 (FOXP1) transcription factor distinguishes the aggressive activated B cell (ABC) diffuse large B-cell lymphoma (DLBCL) subtype from the better prognosis germinal center B-cell (GCB)-DLBCL subtype and is highly correlated with poor outcomes. A genetic or functional role for FOXP1 in lymphomagenesis, however, remains unknown. Here, we report that sustained FOXP1 expression is...

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PMID: 26787899
DOI: 10.1073/pnas.1524677113

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