Article
Alterations in microglial phenotype and hippocampal neuronal function in transgenic mice with astrocyte-targeted production of interleukin-10.
Brain, behavior, and immunity - 1 Mar 2015
Almolda Beatriz, de Labra Carmen, Barrera Iliana, Gruart Agnès, Delgado-Garcia Jose M, Villacampa Nàdia, Vilella Antonietta, Hofer Markus J, Hidalgo Juan, Campbell Iain L, González Berta, Castellano Bernardo
Abstract excerpt
Interleukin-10 (IL-10) is a cytokine classically linked with anti-inflammatory and protective functions in the central nervous system (CNS) in different neurodegenerative and neuroinflammatory conditions. In order to study the specific role of local CNS produced IL-10, we have created a new transgenic mouse line with astrocyte-targeted production of IL-10 (GFAP-IL10Tg). In the present study, the effects of local...
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