Article
Van-Gogh-like 2 antagonises the canonical WNT pathway and is methylated in colorectal cancers.
British journal of cancer - 30 Apr 2013
Piazzi G, Selgrad M, Garcia M, Ceccarelli C, Fini L, Bianchi P, Laghi L, D'Angelo L, Paterini P, Malfertheiner P, Chieco P, Boland C R, Bazzoli F, Ricciardiello L
Abstract excerpt
BACKGROUND: Aberrant activation of the canonical WNT signaling is a feature of colorectal cancer (CRC). Van-Gogh-like 2 (VANGL2) belongs to the non-canonical WNT pathway whose activation inhibits canonical WNT signaling. In this study, we investigated the role of VANGL2 and its epigenetic regulation in CRC. METHODS: Van-Gogh-like 2 expression and promoter methylation after 5-aza-2'-deoxycytidine (5-aza) treatment...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.