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Article

Epigenetic repression of ROR2 has a Wnt-mediated, pro-tumourigenic role in colon cancer

30 Jun 2010

Abstract excerpt

BACKGROUND: Wnt factors control cell differentiation through semi-independent molecular cascades known as the beta-catenin-dependent (canonical) and -independent (non-canonical) Wnt signalling pathways. Genetic and epigenetic alteration of components of the canonical Wnt signalling pathway is one of the primary mechanisms underlying colon cancer. Despite increasing evidence of the role of the non-canonical...

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PMID: 20591152
DOI: 10.1186/1476-4598-9-170

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