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Article

Human three prime exonuclease TREX1 is induced by genotoxic stress and involved in protection of glioma and melanoma cells to anticancer drugs.

Biochimica et biophysica acta - 1 Aug 2013

Tomicic Maja T, Aasland Dorthe, Nikolova Teodora, Kaina Bernd, Christmann Markus

Abstract excerpt

To counteract genotoxic stress, DNA repair functions are in effect. Most of them are constitutively expressed while some of them can be up-regulated depending on the level of DNA damage. In human cells, only few DNA repair functions are subject of induction following DNA damage, and thus there is a need to identify and characterize inducible repair functions more thoroughly. Here, we provide evidence that the...

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Source

Identifiers

PMID: 23578789
DOI: 10.1016/j.bbamcr.2013.03.029

Genes

TREX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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