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Article

Creation of a reactive oxygen species-insensitive Kcv channel.

Biochemistry - 7 May 2013

Schroeder Indra, Gazzarrini Sabrina, Ferrara Giuseppina, Thiel Gerhard, Hansen Ulf-Peter, Moroni Anna

Abstract excerpt

The current of the minimal viral K(+) channel Kcv(PCBV-1) heterologously expressed in Xenopus oocytes is strongly inhibited by reactive oxygen species (ROS) like H(2)O(2). Possible targets for the ROS effect are two cysteines (C53 and C79) and four methionines (M1, M15, M23, and M26). The C53A/C79A and M23L/M26L double mutations maintained the same ROS sensitivity as the wild type. However, M15L as a single...

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PMID: 23578303
DOI: 10.1021/bi3016197

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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