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Article

Gating competence of constitutively open CLC-0 mutants revealed by the interaction with a small organic Inhibitor.

The Journal of general physiology - 1 Sept 2003

Traverso Sonia, Elia Laura, Pusch Michael

Abstract excerpt

Opening of CLC chloride channels is coupled to the translocation of the permeant anion. From the recent structure determination of bacterial CLC proteins in the closed and open configuration, a glutamate residue was hypothesized to form part of the Cl--sensitive gate. The negatively charged side-chain of the glutamate was suggested to occlude the permeation pathway in the closed state, while opening of a single...

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Identifiers

PMID: 12913089
DOI: 10.1085/jgp.200308784
PMCID: PMC2234481

Genes

CLC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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