Modular architecture of K+ channels: the functional plasticity of the pore module.

Abstract excerpt

Miniature K+ channel proteins from viruses (Kcv) are structurally and functionally equivalent to the pore module of all K+ channels. Here, we summarize data in support of the hypothesis that pores of primitive K+ channels served as building blocks for evolving the modern complex mammalian ion channels. Experimental data show that mutations in Kcv channels can generate gating phenomena like slow-activating inward...

Topics

• Ion Channel Gating
• Potassium Channels
• Animals
• Humans
• Protein Domains
• Evolution, Molecular
• Mutation