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Article

Toward the rational design of constitutively active KCa3.1 mutant channels.

Methods in enzymology - 1 Jan 2010

Garneau Line, Klein Hélène, Parent Lucie, Sauvé Rémy

Abstract excerpt

The Ca²+ activated potassium channel of intermediate conductance KCa3.1 is now emerging as a therapeutic target for a large variety of health disorders. KCa3.1 is a tetrameric membrane protein with each subunit formed of six transmembrane helices (S1-S6). Ca²+ sensitivity is conferred by the Ca²+ binding protein calmodulin (CaM), with the CaM C-lobe constitutively bound to an intracellular domain of the channel...

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PMID: 21050931
DOI: 10.1016/B978-0-12-381296-4.00024-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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