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An attenuated replication-competent chikungunya virus with a fluorescently tagged envelope

31 Jul 2018

Abstract excerpt

BackgroundChikungunya virus (CHIKV) is the most common alphavirus infecting humans worldwide, causing acute and chronically debilitating arthralgia at a great economic expense. Methodology/Principal findingsTo facilitate our study of CHIKV, we generated a mCherry tagged replication-competent chimeric virus, CHIKV 37997-mCherry.Single particle cryoEM demonstrated icosahedral organization of the chimeric virus and...

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PMID: 30063703
DOI: 10.1371/journal.pntd.0006693

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