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Article

Pellino1 promotes chronic inflammatory skin disease via keratinocyte hyperproliferation and induction of the T helper 17 response.

Experimental & molecular medicine - 1 Sept 2020

Kim Suhyeon, Lee Si-Yeon, Bae Seoyoon, Lee Jin-Kwan, Hwang Kyungrim, Go Heounjeong, Lee Chang-Woo

Abstract excerpt

Psoriasis is one of the most common immune-mediated chronic inflammatory skin diseases. However, little is known about the molecular mechanism underlying the immunological circuits that maintain innate and adaptive immune responses in established psoriasis. In this study, we found that the Pellino1 (Peli1) ubiquitin E3 ligase is activated by innate pattern-recognition receptors (PRRs), such as Toll-like receptors...

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Source

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Identifiers

PMID: 32873845
DOI: 10.1038/s12276-020-00489-4
PMCID: PMC8080721

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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