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Article

Diet influences expression of autoimmune-associated genes and disease severity by epigenetic mechanisms in a transgenic mouse model of lupus.

Arthritis and rheumatism - 1 Jul 2013

Strickland Faith M, Hewagama Anura, Wu Ailing, Sawalha Amr H, Delaney Colin, Hoeltzel Mark F, Yung Raymond, Johnson Kent, Mickelson Barbara, Richardson Bruce C

Abstract excerpt

OBJECTIVE: Lupus flares occur when genetically predisposed individuals encounter appropriate environmental agents. Current evidence indicates that the environment contributes by inhibiting T cell DNA methylation, causing overexpression of normally silenced genes. DNA methylation depends on both dietary transmethylation micronutrients and ERK-regulated DNA methyltransferase 1 (DNMT-1) levels. We used transgenic...

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Identifiers

PMID: 23576011
DOI: 10.1002/art.37967
PMCID: PMC3735138

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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