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Article

Plekhg4 is a novel Dbl family guanine nucleotide exchange factor protein for rho family GTPases.

The Journal of biological chemistry - 17 May 2013

Gupta Meghana, Kamynina Elena, Morley Samantha, Chung Stacey, Muakkassa Nora, Wang Hong, Brathwaite Shayna, Sharma Gaurav, Manor Danny

Abstract excerpt

Mutations in the PLEKHG4 (puratrophin-1) gene are associated with the heritable neurological disorder autosomal dominant spinocerebellar ataxia. However, the biochemical functions of this gene product have not been described. We report here that expression of Plekhg4 in the murine brain is develo...

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Identifiers

PMID: 23572525
DOI: 10.1074/jbc.M112.430371
PMCID: PMC3656306

Genes

PLEKHG4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23572525-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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