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Article

Wdr4 promotes cerebellar development and locomotion through Arhgap17-mediated Rac1 activation

21 Jan 2023

Abstract excerpt

Patients with mutations of WDR4, a substrate adaptor of the CUL4 E3 ligase complex, develop cerebellar atrophy and gait phenotypes. However, the underlying mechanisms remain unexplored. Here, we identify a crucial role of Wdr4 in cerebellar development. Wdr4 deficiency in granule neuron progenitors (GNPs) not only reduces foliation and the sizes of external and internal granular layers but also compromises...

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PMID: 36681682
DOI: 10.1038/s41419-022-05442-z

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