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Article

Activation of a Potassium Channel Mutation That Causes Spinocerebellar Ataxia Promotes Aggregation of the RhoGEF Domain-Containing Protein Plekhg4.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 30 Apr 2025

Zhang Yalan, Andrawis Anna Simone, Kaczmarek Leonard K

Abstract excerpt

Kv3.3 potassium channels are highly expressed in cerebellar Purkinje neurons and contribute to the ability of these neurons to fire at high rates. In addition to their role in regulating excitability, Kv3.3 channels form a complex with several cytoplasmic proteins, including Hax-1, Arp2/3, Rac1, and TBK1. This stimulates the nucleation of actin filaments under the plasma membrane. Using biochemical and confocal...

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Identifiers

PMID: 40249242
DOI: 10.1096/fj.202402809RR
PMCID: PMC12360067

Genes

TBK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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Activation of a Potassium Channel Mutation That Causes Spinocerebellar Ataxia Promotes Aggregation of the RhoGEF Domain-Containing Protein Plekhg4.PMID 40249242Read ↗

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