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Article

Multiple roles for Pur-α in cellular and viral regulation

1 Feb 2009

Abstract excerpt

Pur-alpha is a ubiquitous multifunctional protein that is strongly conserved throughout evolution, binds to both DNA and RNA and functions in the initiation of DNA replication, control of transcription and mRNA translation. In addition, it binds to several cellular regulatory proteins including the retinoblastoma protein, E2F-1, Sp1, YB-1, cyclin T1/Cdk9 and cyclin A/Cdk2. These observations and functional...

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PMID: 19182532
DOI: 10.4161/cc.8.3.7585

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