Article
Analysis of Latino populations from GALA and MEC studies reveals genomic loci with biased local ancestry estimation.
Bioinformatics (Oxford, England) - 1 Jun 2013
Pasaniuc Bogdan, Sankararaman Sriram, Torgerson Dara G, Gignoux Christopher, Zaitlen Noah, Eng Celeste, Rodriguez-Cintron William, Chapela Rocio, Ford Jean G, Avila Pedro C, Rodriguez-Santana Jose, Chen Gary K, Le Marchand Loic, Henderson Brian, Reich David, Haiman Christopher A, Gonzàlez Burchard Esteban, Halperin Eran
Abstract excerpt
MOTIVATION: Local ancestry analysis of genotype data from recently admixed populations (e.g. Latinos, African Americans) provides key insights into population history and disease genetics. Although methods for local ancestry inference have been extensively validated in simulations (under many unrealistic assumptions), no empirical study of local ancestry accuracy in Latinos exists to date. Hence, interpreting...
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