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Article

Old vs. new local ancestry inference in HCHS/SOL: a comparative study.

Human molecular genetics - 16 Aug 2025

Chen Xueying, Wang Hao, Broce Iris, Dale Anders, Yu Bing, Zhou Laura Y, Li Xihao, Argos Maria, Daviglus Martha L, Cai Jianwen, Franceschini Nora, Sofer Tamar

Abstract excerpt

Hispanic/Latino populations are admixed, with genetic contributions from multiple ancestral populations. To uncover genetic associations in these populations, researchers often turn to admixture mapping, which relies on inferred counts of "local" ancestry, i.e. the source ancestral population at a locus. Local ancestries are inferred using external reference panels that represent ancestral populations, making the...

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PMID: 40485222
DOI: 10.1093/hmg/ddaf093
PMCID: PMC12361116

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