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Article

Variation in genetic admixture and population structure among Latinos: the Los Angeles Latino eye study (LALES).

BMC genetics - 10 Nov 2009

Shtir Corina J, Marjoram Paul, Azen Stanley, Conti David V, Le Marchand Loic, Haiman Christopher A, Varma Rohit

Abstract excerpt

BACKGROUND: Population structure and admixture have strong confounding effects on genetic association studies. Discordant frequencies for age-related macular degeneration (AMD) risk alleles and for AMD incidence and prevalence rates are reported across different ethnic groups. We examined the genomic ancestry characterizing 538 Latinos drawn from the Los Angeles Latino Eye Study [LALES] as part of an ongoing...

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Identifiers

PMID: 19903357
DOI: 10.1186/1471-2156-10-71
PMCID: PMC3087512

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