Article
Oncogenic mutations and microsatellite instability phenotype predict specific anatomical subsite in colorectal cancer patients.
European journal of human genetics : EJHG - 1 Dec 2013
Corso Giovanni, Pascale Valeria, Flauti Giuseppe, Ferrara Francesco, Marrelli Daniele, Roviello Franco
Abstract excerpt
In colorectal cancer (CRC) oncogenic mutations such as KRAS alterations, are considered standard molecular biomarkers that predict the clinical benefit for targeted intervention with epidermal growth factor receptor (EGFR) inhibitors. In addition, these mutations are associated with specific anatomical area in colon tumor development, as BRAF mutations with the microsatellite instability (MSI). In this...
Topics
- Class I Phosphatidylinositol 3-Kinases
- Colorectal Neoplasms
- ErbB Receptors
- Female
- Humans
- Male
- Microsatellite Instability
- Mutation
- Oncogenes
- Phenotype
- Phosphatidylinositol 3-Kinases