Influence of anatomical subsite on the incidence of microsatellite instability, and KRAS and BRAF mutation rates in patients with colon carcinoma.

doi:10.1016/j.prp.2012.07.003

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Article

Influence of anatomical subsite on the incidence of microsatellite instability, and KRAS and BRAF mutation rates in patients with colon carcinoma.

Pathology, research and practice - 15 Oct 2012

Benedix Frank, Meyer Frank, Kube Rainer, Kropf Siegfried, Kuester Doerthe, Lippert Hans, Roessner Albert, Krüger Sabine

Abstract excerpt

There is a growing amount of data supporting the concept that cancers originating from the proximal and distal colon are distinct clinicopathological entities. The incidence of MSI and BRAF mutation is strongly associated with right sided tumor location, whereas there are conflicting results for...

Topics

Aged
Aged, 80 and over
Carcinoma
Cell Differentiation
Chi-Square Distribution
Colonic Neoplasms
DNA Mutational Analysis
Female
Genetic Predisposition to Disease
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microsatellite Instability

Middle Aged

Mutation

Neoplasm Grading

Neoplasm Invasiveness

Neoplasm Staging

Phenotype

Source

Open in PubMed

Identifiers

PMID: 22898351
DOI: 10.1016/j.prp.2012.07.003

Genes

BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-22898351-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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