Article
Modeling breast acini in tissue culture for detection of malignant phenotype reversion to non-malignant phenotype.
Iranian biomedical journal - 1 Oct 2009
Vahidnezhad Hassan, Youssefian Leila, Jeddi-Tehrani Mahmoud, Akhondi Mohammad Mehdi, Rabbani Hojatollah, Shokri Fazel, Tabrizi Mina
Abstract excerpt
BACKGROUNDS: Evidence is accumulating to support disruption of tissue architecture as a powerful event in tumor formation. For the past four decades, intensive cancer research with the premise of "cancer as a cell based-disease" focused on finding oncogenes or tumor suppressor genes. However, the role of the tissue architecture was neglected. Three dimensional (3D) cell cultures which can recapitulate major...
Topics
- Adult
- Biocompatible Materials
- Breast
- Breast Neoplasms
- Cell Communication
- Cell Culture Techniques
- Cell Line, Tumor
- Cell Polarity
- Collagen
- Drug Combinations
- Epithelial Cells
- Female
- Humans
- Imaging, Three-Dimensional