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Article

Modeling breast acini in tissue culture for detection of malignant phenotype reversion to non-malignant phenotype.

Iranian biomedical journal - 1 Oct 2009

Vahidnezhad Hassan, Youssefian Leila, Jeddi-Tehrani Mahmoud, Akhondi Mohammad Mehdi, Rabbani Hojatollah, Shokri Fazel, Tabrizi Mina

Abstract excerpt

BACKGROUNDS: Evidence is accumulating to support disruption of tissue architecture as a powerful event in tumor formation. For the past four decades, intensive cancer research with the premise of "cancer as a cell based-disease" focused on finding oncogenes or tumor suppressor genes. However, the role of the tissue architecture was neglected. Three dimensional (3D) cell cultures which can recapitulate major...

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PMID: 19946344

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