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Article

Prelamin A accelerates vascular calcification via activation of the DNA damage response and senescence-associated secretory phenotype in vascular smooth muscle cells.

Circulation research - 10 May 2013

Liu Yiwen, Drozdov Ignat, Shroff Rukshana, Beltran Leilani E, Shanahan Catherine M

Abstract excerpt

RATIONALE: Vascular calcification is prevalent in the aging population, yet little is known of the mechanisms driving age-associated vascular smooth muscle cell (VSMC) phenotypic change. OBJECTIVE: To investigate the role of nuclear lamina disruption, a specific hallmark of VSMC aging, in driving...

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Source

Identifiers

PMID: 23564641
DOI: 10.1161/CIRCRESAHA.111.300543

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23564641-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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