Article
LMNA mutations resulting in lipodystrophy and HIV protease inhibitors trigger vascular smooth muscle cell senescence and calcification: Role of ZMPSTE24 downregulation.
Atherosclerosis - 1 Feb 2016
Afonso Pauline, Auclair Martine, Boccara Franck, Vantyghem Marie-Christine, Katlama Christine, Capeau Jacqueline, Vigouroux Corinne, Caron-Debarle Martine
Abstract excerpt
BACKGROUND: Some LMNA mutations responsible for lipodystrophies, and some HIV-protease inhibitors (PIs) induce accumulation of farnesylated prelamin A and premature senescence in some cell types. Patients with LMNA mutations or under PI-based therapy suffer from early atherosclerosis. The metalloprotease ZMPSTE24 is the key enzyme in prelamin A maturation. AIM: We studied whether altered expression of ZMPSTE24...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.