Article

Progerin triggers a phenotypic switch in vascular smooth muscle cells that causes replication stress and an aging-associated secretory signature

2022-02-05

Abstract excerpt

<h4>ABSTRACT</h4> Hutchinson Gilford Progeria Syndrome is a premature aging disease caused by LMNA gene mutation and the production of a truncated lamin A protein “progerin” that elicits cellular and organismal toxicity. Progerin accumulates in the vasculature, being especially toxic for vascular smooth muscle cells (VSMC). Patients’ autopsies show that vessel stiffening, and aortic atherosclerosis is accompanie...

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Literature Corpus work: 45e274e9-1978-5ef9-87a7-d91838644b74
DOI: 10.1101/2022.02.05.479232

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