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Mineral Stress Drives Loss of Heterochromatin: An Early Harbinger of Vascular Inflammaging and Calcification

22 Jan 2025

Abstract excerpt

BACKGROUND: Vascular calcification is a detrimental aging pathology markedly accelerated in patients with chronic kidney disease. PLA (prelamin A) is a biomarker of vascular smooth muscle cell aging that accelerates calcification however the mechanisms remain undefined. METHODS: Vascular smooth muscle cells were transduced with PLA using an adenoviral vector and epigenetic modifications were monitored using...

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PMID: 39840455
DOI: 10.1161/circresaha.124.325374

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