Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of SIRT1 in diabetes accelerates DNA damage-induced vascular calcification.

Cardiovascular research - 22 Feb 2021

Bartoli-Leonard Francesca, Wilkinson Fiona L, Schiro Andrew, Serracino Inglott Ferdinand, Alexander M Yvonne, Weston Ria

Abstract excerpt

AIMS: Vascular calcification is a recognized predictor of cardiovascular risk in the diabetic patient, with DNA damage and accelerated senescence linked to oxidative stress-associated pathological calcification. Having previously shown that systemic SIRT1 is reduced in diabetes, the aim was to establish whether SIRT1 is protective against a DNA damage-induced senescent and calcified phenotype in diabetic vascular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acid Anhydride Hydrolases
Share to Ataxia Telangiectasia Mutated Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calcium Chloride

Share to MRE11 Homologue Protein

Share to Myocytes, Smooth Muscle

Share to Osteogenesis

Share to Sirtuin 1

Share to Vascular Calcification

Source

Open in PubMed Open full text

Identifiers

PMID: 32402066
DOI: 10.1093/cvr/cvaa134
PMCID: PMC7898956

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of SIRT1 in diabetes accelerates DNA damage-induced vascular calcification.PMID 32402066Read ↗

The transcription factor GATA6 accelerates vascular smooth muscle cell senescence-related arterial calcification by counteracting the role of anti-aging factor SIRT6 and impeding DNA damage repairSemantic proximity Read ↗

DNA Damage: A Main Determinant of Vascular AgingSemantic proximity Read ↗

Molecular Mechanisms of Vascular Health: Insights From Vascular Aging and CalcificationSemantic proximity Read ↗

Molecular pathways of arterial agingSemantic proximity Read ↗

Molecular mechanism of endothelial and vascular aging: implications for cardiovascular diseaseSemantic proximity Read ↗

Astaxanthin Counteracts Vascular Calcification In Vitro Through an Early Up-Regulation of SOD2 Based on a Transcriptomic Approach.Semantic proximity Read ↗

Prelamin A accelerates vascular calcification via activation of the DNA damage response and senescence-associated secretory phenotype in vascular smooth muscle cells.Semantic proximity Read ↗

DNA damage response, a double-edged sword for vascular agingSemantic proximity Read ↗

Epigenetic modulation of vascular calcification: Looking for comprehending the role of sirt1 and histone acetylation in VSMC phenotypic transition.Semantic proximity Read ↗

Peroxisome Proliferator-Activated Receptor γ Coactivator-1α Is a Central Negative Regulator of Vascular SenescenceSemantic proximity Read ↗

Role of Oxidative and Nitrosative Stress, Longevity Genes and Poly(ADPribose) Polymerase in Cardiovascular Dysfunction Associated with AgingSemantic proximity Read ↗

Role of microRNA-145 in DNA damage signalling and senescence in vascular smooth muscle cells of Type 2 diabetic patientsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.