Article
Multimodal cell maps as a foundation for structural and functional genomics.
Nature - 1 Jun 2025
Schaffer Leah V, Hu Mengzhou, Qian Gege, Moon Kyung-Mee, Pal Abantika, Soni Neelesh, Latham Andrew P, Pontano Vaites Laura, Tsai Dorothy, Mattson Nicole M, Licon Katherine, Bachelder Robin, Cesnik Anthony, Gaur Ishan, Le Trang, Leineweber William, Palar Aji, Pulido Ernst, Qin Yue, Zhao Xiaoyu, Churas Christopher, Lenkiewicz Joanna, Chen Jing, Ono Keiichiro, Pratt Dexter, Zage Peter, Echeverria Ignacia, Sali Andrej, Harper J Wade, Gygi Steven P, Foster Leonard J, Huttlin Edward L, Lundberg Emma, Ideker Trey
Abstract excerpt
Human cells consist of a complex hierarchy of components, many of which remain unexplored1,2. Here we construct a global map of human subcellular architecture through joint measurement of biophysical interactions and immunofluorescence images for over 5,100 proteins in U2OS osteosarcoma cells. Self-supervised multimodal data integration resolves 275 molecular assemblies spanning the range of 10-8 to 10-5 m, which...
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