Article
HIF1α and HIF2α independently activate SRC to promote melanoma metastases.
The Journal of clinical investigation - 1 May 2013
Hanna Sara C, Krishnan Bhavani, Bailey Sean T, Moschos Stergios J, Kuan Pei-Fen, Shimamura Takeshi, Osborne Lukas D, Siegel Marni B, Duncan Lyn M, O'Brien E Tim, Superfine Richard, Miller C Ryan, Simon M Celeste, Wong Kwok-Kin, Kim William Y
Abstract excerpt
Malignant melanoma is characterized by a propensity for early lymphatic and hematogenous spread. The hypoxia-inducible factor (HIF) family of transcription factors is upregulated in melanoma by key oncogenic drivers. HIFs promote the activation of genes involved in cancer initiation, progression, and metastases. Hypoxia has been shown to enhance the invasiveness and metastatic potential of tumor cells by...
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