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The role of Hypoxia-Inducible Factor-1alpha and its signaling in melanoma

2 Jul 2021

Abstract excerpt

Adaptation to the loss of O2 is regulated via the activity of hypoxia-inducible factors such as Hypoxia-Inducible Factor-1 (HIF-1). HIF-1 acts as a main transcriptional mediator in the tissue hypoxia response that regulates over 1000 genes related to low oxygen tension. The role of HIF-1α in oncogenic processes includes angiogenesis, tumor metabolism, cell proliferation, and metastasis, which has been examined in...

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PMID: 34225012
DOI: 10.1016/j.biopha.2021.111873

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