Article
Mutant V600E BRAF increases hypoxia inducible factor-1alpha expression in melanoma.
Cancer research - 1 Apr 2007
Kumar Suresh M, Yu Hong, Edwards Robin, Chen Lianjun, Kazianis Steven, Brafford Patricia, Acs Geza, Herlyn Meenhard, Xu Xiaowei
Abstract excerpt
Mutations in the BRAF serine/threonine kinase gene are frequently found in cutaneous melanomas. Activation of hypoxia inducible factor-1alpha (HIF-1alpha) in response to both hypoxic stress and oncogenic signals has important implications in cancer development and progression. Here, we report that mutant BRAF(V600E) increases HIF-1alpha expression in melanoma cells. Our microarray profiling data in 35 melanoma...
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