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Article

Snail1 mediates hypoxia-induced melanoma progression.

The American journal of pathology - 1 Dec 2011

Liu Shujing, Kumar Suresh M, Martin James S, Yang Ruifeng, Xu Xiaowei

Abstract excerpt

Tumor hypoxia is a known adverse prognostic factor, and the hypoxic dermal microenvironment participates in melanomagenesis. High levels of hypoxia inducible factor (HIF) expression in melanoma cells, particularly HIF-2α, is associated with poor prognosis. The mechanism underlying the effect of hypoxia on melanoma progression, however, is not fully understood. We report evidence that the effects of hypoxia on...

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Identifiers

PMID: 21996677
DOI: 10.1016/j.ajpath.2011.08.038
PMCID: PMC3260799

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