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Article

miR-411 is up-regulated in FSHD myoblasts and suppresses myogenic factors

5 Apr 2013

Abstract excerpt

BACKGROUND: Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant muscle disorder, which is linked to the contraction of the D4Z4 array at chromosome 4q35. Recent studies suggest that this shortening of the D4Z4 array leads to aberrant expression of double homeobox protein 4 (DUX4) and causes FSHD. In addition, misregulation of microRNAs (miRNAs) has been reported in muscular dystrophies...

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PMID: 23561550
DOI: 10.1186/1750-1172-8-55

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miR-411 is up-regulated in FSHD myoblasts and suppresses myogenic factorsPMID 23561550Read ↗

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P38α Regulates Expression of DUX4 in Facioscapulohumeral Muscular DystrophySemantic proximity Read ↗

DUX4c Is Up-Regulated in FSHD. It Induces the MYF5 Protein and Human Myoblast ProliferationSemantic proximity Read ↗

FSHD muscular dystrophy region gene 1 binds Suv4-20h1 histone methyltransferase and impairs myogenesis.Semantic proximity Read ↗

The FSHD atrophic myotube phenotype is caused by DUX4 expression.Semantic proximity Read ↗

Dynamic transcriptomic analysis reveals suppression of PGC1α/ERRα drives perturbed myogenesis in facioscapulohumeral muscular dystrophySemantic proximity Read ↗

Expression profiling of FSHD muscle supports a defect in specific stages of myogenic differentiation.Semantic proximity Read ↗

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