Article
Expression profiling of FSHD muscle supports a defect in specific stages of myogenic differentiation.
Human molecular genetics - 15 Nov 2003
Winokur Sara T, Chen Yi-Wen, Masny Peter S, Martin Jorge H, Ehmsen Jeffrey T, Tapscott Stephen J, van der Maarel Silvere M, Hayashi Yukiko, Flanigan Kevin M
Abstract excerpt
The neuromuscular disorder facioscapulohumeral muscular dystrophy (FSHD) results from integral deletions of the subtelomeric repeat D4Z4 on chromosome 4q. A disruption of chromatin structure affecting gene expression is thought to underlie the pathophysiology. The global gene expression profiling of mature muscle tissue presented here provides the first insight into an FSHD-specific defect in myogenic...
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