Article

P38α Regulates Expression of DUX4 in Facioscapulohumeral Muscular Dystrophy

2019-07-12

Abstract excerpt

<h4>ABSTRACT</h4> FSHD is caused by the loss of repression at the D4Z4 locus leading to DUX4 expression in skeletal muscle, activation of its early embryonic transcriptional program and muscle fiber death. While progress toward understanding the signals driving DUX4 expression has been made, the factors and pathways involved in the transcriptional activation of this gene remain largely unknown. Here, we describe...

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Literature Corpus work: ebfc5c5e-ef52-5429-addb-e3fad6e7621c
DOI: 10.1101/700195

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