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Article

Wnt/β-Catenin Signaling Regulates Telomerase in Stem Cells and Cancer Cells

21 Jun 2012

Abstract excerpt

Telomerase activity controls telomere length and plays a pivotal role in stem cells, aging, and cancer. Here, we report a molecular link between Wnt/β-catenin signaling and the expression of the telomerase subunit Tert. β-Catenin-deficient mouse embryonic stem (ES) cells have short telomeres; conversely, ES cell expressing an activated form of β-catenin (β-cat(ΔEx3/+)) have long telomeres. We show that β-catenin...

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PMID: 22723415
DOI: 10.1126/science.1218370

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